Investigating the contribution of transposable elements and endogenous retroviruses to gene deregulation and pathogenesis of neuroblastoma.
Researchers
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Leila Jahangiri
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Tara Hurst
Research background
Neuroblastoma (NB) is a paediatric cancer of neural crest origin in which the amplification of is the strongest indicator of poor prognosis.
In this study, we are testing the hypothesis that transposable elements (TEs), including HERVs, may play a role in the pathogenesis of NB.
We are currently investigating the presence and expression of TEs including HERVs in NB and their potential contribution to malignant transformation using data we have generated from computational identification of TEs in NB WGS data.