Dr Irmgard Haussmann

Associate Professor in Health Sciences

Email:: Irmgard.Haussmann@bcu.ac.uk

Irmgard is an Associate Professor in Health Sciences and teaches at undergraduate and postgraduate level.

In her role as Director of Postgraduate Research Degrees for Life and Sport she leads all aspects of recruitment and student experiences for PhD Life and Sport Sciences.

Having previously worked at Brandeis University (USA), University of Birmingham and Coventry University Irmgard brings many years of high quality research and teaching experience to BCU.

Irmgard is passionate about her research and publishes with publications in peer reviewed journals, and her work is presented at national and international conferences. Her main research interest is in posttranscriptional gene regulation.

During Irmgard’s PhD at the University of Berne, Switzerland, she was introduced into the importance of RNA binding proteins in gene regulation. She continued to work on RNA with a focus on posttranscriptional gene regulation. Posttranscriptional gene regulation is still an emerging research area and its aberrant regulation has been implicated in numerous diseases including cancer and neurodegeneration.

Recently Irmgard’s research also focus the emerging field of epitranscriptomics determining the function of modified nucleotides in mRNA

Areas of Expertise

Qualifications

Memberships

Teaching

Research

Publications

Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring required for female reproductive behaviors in Drosophila

Irmgard U. Haussmann, Mohanakarthik P. Nallasivan, Daniela Scocchia, Alberto Civetta, Matthias Soller
bioRxiv 806380; doi: https://doi.org/10.1101/806380

Ustaoglu, P., Haussmann, I.U., Torres-Mendez, A., Liao, H., Arnold, R., Irimia, M. and Soller, M. (2019) Srrm234, but not canonical SR and hnRNP proteins drive inclusion of Down Syndrome Cell Adhesion Molecule exon 9 variable exons. RNA. 2019 Oct; 25(10):1353-1365

Haussmann, I. U., Ustaoglu, P., Brauer, U., Hemani, Y., Dix, T. and Soller, M. (2019) Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing of Down Syndrome Cell Adhesion Molecule exon 4 NAR 47:1389-1403

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

Knuckles P, Lence T, Haussmann IU, Jacob D, Kreim N, Carl SH, Masiello I, Hares T, Villaseñor R, Hess D, Andrade-Navarro MA, Biggiogera M, Helm M, Soller M, Bühler M, Roignant JY Genes Dev. 2018 Mar

Haussmann, I.U., Bodi, Z., Sanchez-Moran, E., Mongan, N., Archer, N., Fray, R., and Soller, M. (2016) m6A in Sxl pre-mRNA potentiates alternative splicing for robust Drosophila sex determination. Nature 2016 Dec 540: 301–304

Dezi, V., Ivanov, C., Haussmann, I. U. and Soller, M. (2016) mRNA modifications and their role in development and disease. Biochem Soc Trans. 2016 Oct. Invited mini-review

Zaharieva, E., Haussmann, I. U., Brauer, U. and Soller, M. (2015) Concentration and localization of co-expressed ELAV/Hu family proteins control specificity of mRNA processing MCB 2015 Sept 18:3103-3255 Selected for journal cover

Zaharieva, E., Haussmann, I. U equally contributing authors Haussmann, I. U., Hemani, Y., Wjiesekera, T., Dauwalder, B. and Soller, M. (2013) Multiple pathways mediate the sex-peptide-regulated switch in female Drosophila reproductive behaviors Proc Biol Sci. 2013 Oct 2; 280(1771):2013

Haussmann, I. U., Li, M. and Soller, M. (2011). ELAV mediated 3’-end processing of ewg transcripts is evolutionary conserved despite sequence degeneration of the ELAV binding site. Genetics. 189: 97-107

Haussmann, I.U. and Soller, M. (2010). Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. Dev. Biol. 348: 224-230. Selected for journal cover

Haussmann, I.U., White, K. and Soller, M., (2008). Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. Genome Biol. 9: 73.1-17 Selected for journal cover

Soller, M., Haussmann, I.U., Hollmann, M., Choffat, Y., White, K., Kubli, E. and Schafer, M.A. (2006). Sex-peptide-regulated female sexual behavior requires a subset of ascending ventral nerve cord neurons. Curr. Biol. 16: 1771-1782

Zhaobing D., Haussmann I. U., Ottiger M., Kubli E. (2003). Sex-Peptides Bind Two Molecularly Different Targets in Drosophila melanogaster Females. J. of Neurobiology 55: 372-384, 2003 Selected for journal cover

Bantle S., Keller S., Haussmann I. U., Auerbach D., Muehlebach S. and Perriard J.C. (1996). Tissue specific isoforms of chicken myomesin are generated from one gene J Biol Chem 271: 19042-52, 1996

Günthert U., Hoffmann M., Rudy W., Reber S., Zoller M., Haussmann I. U.., Matzku S.,
Wenzel A., Ponta H., Herrlich P.: A New Variant of Glycoprotein CD44 Confers Metastatic Potential to Rat Carcinoma Cells. Cell 65: 13-24, 1991

Other publications

Soller, M., Li, M. and Haussmann, I.U. (2010). Determinants of ELAV gene-specific regulation. Biochem. Soc. Trans. 38: 1122-4. Invited mini-review

Soller, M., Li, M. and Haussmann, I.U. (2008). Regulation of the ELAV target ewg: insights from an evolutionary perspective. Biochem. Soc. Trans. 36: 502-504. Invited mini-review

Haussmann, I.U., Wu, Y., Archer, N., Bodi, Z., Sanchez-Moran, E., Mongan, N., Archer, N., Fray, R., Waddell, S. and Soller, M. (2020) Cap 2’-O-methylation is required for learning in Drosophila. Submitted to Science