Dr Robert Marshall
Rob is a molecular microbiologist with ten years of doctoral and post-doctoral research experience, mainly in the field of antibiotic resistance.
Rob also has experience of working in a molecular diagnostics environment, at the Rosalind Franklin Laboratory during the CoViD-19 response. This experience contributes primarily to the teaching of the Biomedical Sciences course.
Areas of Expertise
- Molecular microbiology
Qualifications
- PhD Bioscience
- MSc Molecular Biotechnology
- BSc (Hons) Medical Biochemistry
Memberships
Rob is a member of the Microbiology Society.
Teaching
Rob currently teaches on the following courses:
- BSc Biomedical Science
- BSc Nursing
Publications
Mira N.P., Marshall R., Pinheiro M.J.F., Dieckmann R., Al Dahouk S., Skroza N., Rudnicka K., Lund P.A. and De Biase D. (2024) On the potential role of naturally occurring carboxylic organic acids as anti-infective agents: opportunities and challenges. International Journal of Infectious Diseases 140, pp.119-123. doi.org/10.1016/j.ijid.2024.01.011
Ciusa M.L., Marshall R.L., Ricci V., Stone J.W. and Piddock L.J.V. (2022) Absence, loss-of-function or inhibition of Escherichia coli AcrB does not increase expression of other efflux pumps supporting the discovery of AcrB inhibitors as antibiotic adjuvants. Journal of Antimicrobial Chemotherapy 77(3), pp.633-640. doi.org/10.1093/jac/dkab45
Moolla N., Bailo R., Marshall R., Bavro V.N. and Bhatt A. (2021) Structure-function analysis of MmpL7-mediated lipid transport in mycobacteria. The Cell Surface 7, e100062. doi.org/10.1016/j.tcsw.2021.100062
Marshall R.L., and Bavro V.N. (2020) Mutations in the TolC periplasmic domain affect substrate specificity of the AcrAB-TolC pump. Frontiers in Molecular Biosciences 7, e00166 doi.org/10.3389/fmolb.2020.00166
Marshall R.L., Lloyd G.S., Lawler A.J., Element S.J., Kaur J., Ciusa M.L., Ricci V., Tschumi A., Kühne H., Alderwick L.J. and Piddock L.J.V. (2020) New multidrug efflux inhibitors for Gram-negative bacteria. mBio 11(4) e01340-20 doi.org/10.1128/mbio.01340-20
Johnson R.M.; Fais C.; Parmar M.; Cheruvara H.; Marshall R.L.; Hesketh S.J.; Feasey M.C.; Ruggerone P.; Vargiu A.V.; Postis V.L.G., Muench S.P. and Bavro V.N. (2020) Cryo-EM structure and molecular dynamics analysis of the fluoroquinolone resistant mutant of the AcrB transporter from Salmonella. Microorganisms 8, a943. doi.org/10.3390/microorganisms8060943
Grimsey E.M., Fais C., Marshall R.L., Ricci V., Ciusa M.L., Stone J.W., Ivens A., Malloci G., Ruggerone P., Vargiu A.V., Piddock L.J.V. (2020) Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump. mBio11(3) e00465-20. doi.org/10.1128/mbio.00465-20
Javid A., Cooper C., Singh A., Schindler S., Hänisch M., Marshall R.L., Kalscheuer R., Bavro V.N. and Bhatt A. (2019) The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow-growing mycobacteria. Molecular Microbiology 113(2) pp.521-533. doi.org/10.1111/mmi.14437
Symmons M.F., Marshall R.L. and Bavro V.N. (2015) Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies. Frontiers in Microbiology 6, e00513. doi.org/10.3389/fmicb.2015.00513
Johnson M.D., Bell J., Clarke K., Chandler R., Pathak P., Xia Y., Marshall R.L., Weinstock G.M., Loman N.J., Winn P.J. and Lund P.A. (2014) Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli. Molecular Microbiology 93(5) pp.911-927. doi.org/10.1111/mmi.12704